abstract：BACKGROUND:Cannabinoid type-1 (CB1) receptor inverse agonists improve type 2 diabetes and dyslipidaemia but were discontinued due to adverse psychiatric effects. Δ(9)-Tetrahydrocannabivarin (THCV) is a neutral CB1 antagonist producing hypophagia and body weight reduction in lean mice. We investigated its effects in die...

journal_title：Nutrition & diabetes

authors： Wargent ET,Zaibi MS,Silvestri C,Hislop DC,Stocker CJ,Stott CG,Guy GW,Duncan M,Di Marzo V,Cawthorne MA

更新日期：2013-05-27 00:00:00

abstract：BACKGROUND:Individuals who focused on calorie counting lost more weight than those who focused on increasing vegetable and fruit (V&F) intake in a weight loss program. We now present serum carotenoid data (biomarkers of V&F intake) from both groups and test whether these biomarkers correlate with changes in weight and ...

journal_title：Nutrition & diabetes

authors： Whigham LD,Valentine AR,Johnson LK,Zhang Z,Atkinson RL,Tanumihardjo SA

更新日期：2012-10-01 00:00:00

abstract：BACKGROUND AND DESIGN:Adiponectin is an adipokine secreted primarily from adipose tissue that can influence circulating plasma glucose and lipid levels through multiple mechanisms involving a variety of organs. In humans, reduced plasma adiponectin levels induced by obesity are associated with insulin resistance and ty...

journal_title：Nutrition & diabetes

authors： Kandasamy AD,Sung MM,Boisvenue JJ,Barr AJ,Dyck JR

更新日期：2012-09-10 00:00:00

abstract：:Obesity and related complications are major health burdens. Almost 700 million adults are currently obese globally and the prevalence is predicted to rise towards 2030. The sudden change of lifestyle with physical inactivity and excessive calorie intake undoubtedly have a major part of the epidemic development; howeve...

journal_title：Nutrition & diabetes

authors： Sandholt CH,Hansen T,Pedersen O

更新日期：2012-07-30 00:00:00

abstract：:Human obesity has evolved into a global epidemic. Interestingly, a similar trend has been observed in many animal species, although diet composition, food availability and physical activity have essentially remained unchanged. This suggests a common factor-potentially an environmental factor affecting all species. Coi...

journal_title：Nutrition & diabetes

authors： Hersoug LG,Sjödin A,Astrup A

更新日期：2012-03-05 00:00:00

abstract：OBJECTIVE:To examine the social and behavioural correlates of metabolic phenotypes during 'at-risk' and 'case' stages of the metabolic disease continuum. DESIGN:Cross-sectional study of a random population sample. PARTICIPANTS:A total of 718 community-dwelling adults (57% female), aged 18-92 years from a regional Sou...

journal_title：Nutrition & diabetes

authors： Haren MT,Misan G,Grant JF,Buckley JD,Howe PR,Taylor AW,Newbury J,McDermott RA

更新日期：2012-01-16 00:00:00

abstract：OBJECTIVE:Along with the increasing prevalence of obesity and related diseases, particularly atherosclerotic diseases, metabolic syndrome (MetS) is now a common and major public health issue in many countries around the world. Adiponectin, a protein secreted by the adipose tissue, has become recognized as a key player ...

journal_title：Nutrition & diabetes

authors： Baden MY,Yamada Y,Obata Y,Hosakawa Y,Saisho K,Tamba S,Yamamoto K,Umeda M,Furubayashi A,Tsukamoto Y,Matsuzawa Y

更新日期：2011-10-10 00:00:00

abstract：OBJECTIVE:Microfibrillar-associated protein 5 (MFAP5) is an extracellular matrix (ECM) glycoprotein, which is colocalized with microfibrils in elastin networks. Its function in adipose tissue (AT) is not known. We have recently shown that the expression of MFAP5 is downregulated in AT along with weight reduction (WR) i...

journal_title：Nutrition & diabetes

authors： Vaittinen M,Kolehmainen M,Schwab U,Uusitupa M,Pulkkinen L

更新日期：2011-08-29 00:00:00

abstract：OBJECTIVE:The gut microbiota contribute otherwise impossible metabolic functions to the human host. Shifts in the relative proportions of gut microbial communities in adults have been correlated with intestinal disease and have been associated with obesity. The aim of this study was to elucidate differences in gut micr...

journal_title：Nutrition & diabetes

authors： Payne AN,Chassard C,Zimmermann M,Müller P,Stinca S,Lacroix C

更新日期：2011-07-18 00:00:00

abstract：OBJECTIVE:Statin therapy reduces coronary heart disease (CHD) and mortality in individuals with elevated C-reactive protein (CRP) but low-density lipoprotein cholesterol below the threshold at which statin therapy is recommended. We determined the proportion of individuals with elevated CRP in whom statin therapy was n...

journal_title：Nutrition & diabetes

authors： Khoo CM,Tan M,Wu Y,Wai CH,Subramaniam T,Lee J,Tai ES

更新日期：2011-05-23 00:00:00